"Knowledge being to be had only of visible and certain truth, error is not a fault of our knowledge, but a mistake of our judgment, giving assent to that which is not true." (John Locke, "An Essay Concerning Human Understanding", 1689)
"Assert nothing till after repeated experiments and examinations, in all lights, and in all positions. Truth alone is the matter that you are in search after; and if you have been mistaken, let not vanity seduce you to persist in your mistake." (Henry Baker, "The Microscope Made Easy", 1742)
"The only method of preventing such errors from taking place, and of correcting them when formed, is to restrain and simplify our reasoning as much as possible. This depends entirely upon ourselves, and the neglect of it is the only source of our mistakes." (Antoine-Laurent de Lavoisier, "Elements of Chemistry in a New Systematic Order", 1790)
"Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you mustn't mistake the scaffolding for the building." (Johann Wolfgang von Goethe, "Maxims and Reflections", 1833)
"Experimental science hardly ever affords us more than approximations to truth; and whenever many agents are concerned we are in great danger of being mistaken." (Sir Humphry Davy, cca. 1836)
"We learn wisdom from failure much more than from success. We often discover what will do, by finding out what will not do; and probably he who never made a mistake never made a discovery." (Samuel Smiles, "Facilities and Difficulties", 1859)
"It has often been said that, to make discoveries, one must be ignorant. This opinion, mistaken in itself, nevertheless conceals a truth. It means that it is better to know nothing than to keep in mind fixed ideas based on theories whose confirmation we constantly seek, neglecting meanwhile everything that fails to agree with them." (Claude Bernard, "An Introduction to the Study of Experimental Medicine", 1865)
"It is surprising to learn the number of causes of error which enter into the simplest experiment, when we strive to attain rigid accuracy." (William S Jevons, "The Principles of Science: A Treatise on Logic and Scientific Method", 1874)
"Perfect readiness to reject a theory inconsistent with fact is a primary requisite of the philosophic mind. But it, would be a mistake to suppose that this candour has anything akin to fickleness; on the contrary, readiness to reject a false theory may be combined with a peculiar pertinacity and courage in maintaining an hypothesis as long as its falsity is not actually apparent. (William S Jevons, "The Principles of Science", 1874)
"There cannot be a greater mistake than that of looking superciliously upon the practical applications of science. The life and soul of science is its practical application; and just as the great advances in mathematics have been made through the desire of discovering the solution of problems which were of a highly practical kind in mathematical science, so in physical science many of the greatest advances that have been made from the beginning of the world to the present time have been made in earnest desire to turn the knowledge of the properties of matter to some purpose useful to mankind." (William T Kelvin, "Electrical Units of Measurement", 1883)
"It sounds paradoxical to say the attainment of scientific truth has been effected, to a great extent, by the help of scientific errors." (Thomas H Huxley, "The Progress of Science", 1887)
"The man of science, who, forgetting the limits of philosophical inquiry, slides from these formulæ and symbols into what is commonly understood by materialism, seems to me to place himself on a level with the mathematician, who should mistake the x's and y's with which he works his problems for real entities - and with this further disadvantage, as compared with the mathematician, that the blunders of the latter are of no practical consequence, while the errors of systematic materialism may paralyse the energies and destroy the beauty of a life." (Thomas H Huxley, "Method and Results", 1893)
"The scientific spirit is of more value than its products, and irrationally held truths may be more harmful than reasoned errors." (Thomas H Huxley, "Darwiniana", 1893–94)
"The folly of mistaking a paradox for a discovery, a metaphor for a proof, a torrent of verbiage for a spring of capital truths, and oneself for an oracle, is inborn in us." (Paul Valéry, "Introduction to the Method of Leonardo da Vinci", 1895)
"It is a great mistake to suppose that the mind of the active scientist is filled with pro-positions which, if not proved beyond all reasonable cavil, are at least extremely probable. On the contrary, he entertains hypotheses which are almost wildly incredible, and treats them with respect for the time being. Why does he do this? Simply because any scientific proposition whatever is always liable to be refuted and dropped at short notice. A hypothesis is something which looks as if it might be true and were true, and which is capable of verification or refutation by comparison with facts. The best hypothesis, in the sense of the one most recommending itself to the inquirer, is the one which can be the most readily refuted if it is false." (Charles S Peirce, 1896)
"The scientific value of truth is not, however, ultimate or absolute. It rests partly on practical, partly on aesthetic interests. As our ideas are gradually brought into conformity with the facts by the painful process of selection, - for intuition runs equally into truth and into error, and can settle nothing if not controlled by experience, - we gain vastly in our command over our environment. This is the fundamental value of natural science" (George Santayana, "The Sense of Beauty: Being the Outlines of Aesthetic Theory", 1896)
"It would be a mistake to suppose that a science consists entirely of strictly proved theses, and it would be unjust to require this. […] Science has only a few apodeictic propositions in its catechism: the rest are assertions promoted by it to some particular degree of probability. It is actually a sign of a scientific mode of thought to find satisfaction in these approximations to certainty and to be able to pursue constructive work further in spite of the absence of final confirmation." (Sigmund Freud, "Introductory Lectures on Psycho-Analysis", 1916)
"The mistake from which todays’ science suffers is that the theoreticians are concerned too unilaterally with precision mathematics, while the practitioners use a sort of approximate mathematics, without being in touch with precision mathematics through which they could reach a real approximation mathematics." (Felix Klein, "Elementary Mathematics from a Higher Standpoint" Vol III: "Precision Mathematics and Approximation Mathematics", 1928)
"More than any other science, mathematics develops through a sequence of consecutive abstractions. A desire to avoid mistakes forces mathematicians to find and isolate the essence of problems and the entities considered. Carried to an extreme, this procedure justifies the well-known joke that a mathematician is a scientist who knows neither what he is talking about nor whether whatever he is talking about exists or not." (Élie Cartan, 1940)
"Men of science have made abundant mistakes of every kind; their knowledge has improved only because of their gradual abandonment of ancient errors, poor approximations, and premature conclusions." (George Sarton, "A History of Science" Vol 2, 1952)
"Nature is more subtle, more deeply intertwined and more strangely integrated than any of our pictures of her - than any of our errors. It is not merely that our pictures are not full enough; each of our pictures in the end turns out to be so basically mistaken that the marvel is that it worked at all." (Jacob Bronowski, "The Common Sense of Science", 1953)
"Men of science have made abundant mistakes of every kind; their knowledge has improved only because of their gradual abandonment of ancient errors, poor approximations, and premature conclusions." (George Sarton, "A History of Science" Vol. 2, 1959)
"[…] the progress of science is a little like making a jig-saw puzzle. One makes collections of pieces which certainly fit together, though at first it is not clear where each group should come in the picture as a whole, and if at first one makes a mistake in placing it, this can be corrected later without dismantling the whole group." (Sir George Thomson, "The Inspiration of Science", 1961)
"All discoveries in art and science result from an accumulation of errors." (Marshall McLuhan, "Culture Is Our Business", 1970)
"Early scientific thinking was holistic, but speculative - the modern scientific temper reacted by being empirical, but atomistic. Neither is free from error, the former because it replaces factual inquiry with faith and insight, and the latter because it sacrifices coherence at the altar of facticity. We witness today another shift in ways of thinking: the shift toward rigorous but holistic theories. This means thinking in terms of facts and events in the context of wholes, forming integrated sets with their own properties and relationships." (Ervin László, "Introduction to Systems Philosophy", 1972)
"The point is that every experiment involves an error, the magnitude of which is not known beforehand and it varies from one experiment to another. For this reason, no matter what finite number of experiments have been carried out, the arithmetic mean of the values obtained will contain an error. Of course, if the experiments are conducted under identical conditions and the errors are random errors, then the error of the mean will diminish as the number of experiments is increased, but it cannot be reduced to zero for a finite number of experiments. […] The choice of entities for an experiment must be perfectly random, so that even an apparently inessential cause could not lead to erroneous conclusions." (Yakov Khurgin, "Did You Say Mathematics?", 1974)
"[…] in most sciences the question Why? is forbidden and the answer is actually to the question, How? Science is much better in explaining than in understanding, but it likes to mistake one for the other." (Erwin Chargaff, "Voices in the Labyrinth", Perspectives in Biology and Medicine Vol. 18, 1975)
"Early scientific thinking was holistic, but speculative - the modern scientific temper reacted by being empirical, but atomistic. Neither is free from error, the former because it replaces factual inquiry with faith and insight, and the latter because it sacrifices coherence at the altar of facticity. We witness today another shift in ways of thinking: the shift toward rigorous but holistic theories. This means thinking in terms of facts and events in the context of wholes, forming integrated sets with their own properties and relationships." (Ervin László, "Introduction to Systems Philosophy", 1972)
"Whatever humans have learned had to be learned as a consequence only of trial and error experience. Humans have learned only through mistakes." (Buckminster Fuller, "R Buckminster Fuller on education", 1979)
"What shows a theory to be inadequate or mistaken is not, as a rule, the discovery of a mistake in the information that led us to propound it; more often it is the contradictory evidence of a new observation which we were led to make because we held that theory." (Sir Peter B Medawar, "Pluto’s Republic: Incorporating the Art of the Soluble and Induction Intuition in Scientific Thought", 1982)
"Science usually amounts to a lot more than blind trial and error. Good statistics consists of much more than just significance tests; there are more sophisticated tools available for the analysis of results, such as confidence statements, multiple comparisons, and Bayesian analysis, to drop a few names. However, not all scientists are good statisticians, or want to be, and not all people who are called scientists by the media deserve to be so described." (Robert Hooke, "How to Tell the Liars from the Statisticians", 1983)
"Humans may crave absolute certainty; they may aspire to it; they may pretend, as partisans of certain religions do, to have attained it. But the history of science - by far the most successful claim to knowledge accessible to humans - teaches that the most we can hope for is successive improvement in our understanding, learning from our mistakes, an asymptotic approach to the Universe, but with the proviso that absolute certainty will always elude us. We will always be mired in error. The most each generation can hope for is to reduce the error bars a little, and to add to the body of data to which error bars apply." (Carl Sagan, "The Demon-Haunted World: Science as a Candle in the Dark", 1995)
"It is important to distinguish between the scientific concept of law as a generalization, and the social concept of law which is prescriptive and normative. A desire for tolerance in respecting the laws of different social systems must not lead us into the mistake of attributing volition to the entities of science or relativism to scientific laws."
"The human mind delights in finding pattern - so much so that we often mistake coincidence or forced analogy for profound meaning. No other habit of thought lies so deeply within the soul of a small creature trying to make sense of a complex world not constructed for it." (Stephen J Gould, "The Flamingo's Smile: Reflections in Natural History", 2010)
"No definition of a social problem is perfect, but there are two principal ways such definitions can be flawed. On the one hand, we may worry that a definition is too broad, that it encompasses more than it ought to include. That is, broad definitions identify some cases as part of the problem that we might think ought not to be included; statisticians call such cases false positives (that is, they mistakenly identify cases as part of the problem). On the other hand, a definition that is too narrow excludes cases that we might think ought to be included; these are false negatives (incorrectly identified as not being part of the problem)." (Joel Best, "Damned Lies and Statistics: Untangling Numbers from the Media, Politicians, and Activists", 2001)
"One should never mistake pattern for meaning." (Iain Banks, "The Hydrogen Sonata", 2012)
"A theory is a supposition which we hope to be true, a hypothesis is a supposition which we expect to be useful; fictions belong to the realm of art; if made to intrude elsewhere, they become either make-believes or mistakes." (G Johnstone Stoney)
"Science with its strict analysis of the facts, its persevering search for new, more consummate truths, and its relentless struggle against discovered mistakes and prejudices - science must saturate all or technics, our culture, and everyday life." (Abram F Joffe)
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