"[…] the distinction between rigorous thinking and more vague ‘imaginings’; even in mathematics itself, all is not a question of rigor, but rather, at the start, of reasoned intuition and imagination, and, also, repeated guessing. After all, most thinking is a synthesis or juxtaposition of advances along a line of syllogisms - perhaps in a continuous and persistent ‘forward'’ movement, with searching, so to speak ‘sideways’, in directions which are not necessarily present from the very beginning and which I describe as ‘sending out exploratory patrols’ and trying alternative routes." (Stanislaw M Ulam, "Adventures of a Mathematician", 1976)
"Mathematics does not grow through a monotonous increase of the number of indubitably established theorems, but through the incessant improvement of guesses by speculation and criticism." (Imre Lakatos, "Proofs and Refutations", 1976)
"That an educated guess about something would sound better if he called it a model?" (Robert L Bates, "Petulant Questions", Geotimes Vol. 22 (6), 1977)
"The truth is not in nature waiting to declare itself, and we cannot know a priori which observations are relevant and which are not; every discovery, every enlargement of the understanding begins as an imaginative preconception of what the truth might be. This imaginative preconception - a 'hypothesis' - arises by a process as easy or as difficult to understand as any other creative act of mind; it is a brainwave, an inspired guess, the product of a blaze of insight. It comes, anyway, from within and cannot be arrived at by the exercise of any known calculus of discovery." (Sir Peter B Medawar, "Advice to a Young Scientist", 1979)
"A mathematician’s work is mostly a tangle of guesswork, analogy, wishful thinking and frustration, and proof, far from being the core of discovery, is more often than not a way of making sure that our minds are not playing tricks." (Gian-Carlo Rota, 1981)
"We often hear that mathematics consists mainly in ‘proving theorems’. Is a writer’s job mainly that of ‘writing sentences’? A mathematician’s work is mostly a tangle of guesswork, analogy, wishful thinking and frustration, and proof, far from being the core of discovery, is more often than not a way of making sure that our minds are not playing tricks." (Gian-Carlo Rota, "Complicating Mathematics" in "Discrete Thoughts", 1981)
"Valid physical questions face us for which our physics is utterly inadequate. This can only be a sign that we stand at a great frontier of science, one that will form a cutting edge of inquiry for generations to come, with results we cannot guess." (Alan MacRobert, "Beyond the Big Bang", Sky & Telescope, Vol 65–66, 1983)
"Mathematics is not a deductive science - that’s a cliché. When you try to prove a theorem, you don’t just list the hypotheses, and then start to reason. What you do is trial and error, experimentation, guesswork." (Paul R Halmos, "I Want to Be a Mathematician", 1985)
"Because mathematical proofs are long, they are also difficult to invent. One has to construct, without making any mistakes, long chains of assertions, and see what one is doing, see where one is going. To see means to be able to guess what is true and what is false, what is useful and what is not. To see means to have a feeling for which definitions one should introduce, and what the key assertions are that will allow one to develop a theory in a natural manner." (David Ruelle, "Chance and Chaos", 1991)
"Even distinguished philosophers of science [...] recognize the failure of philosophy to help understand the nature of science. They have not discovered a scientific method that provides a formula or prescriptions for how to make discoveries. But many famous scientists have given advice: try many things; do what makes your heart leap; think big; dare to explore where there is no light; challenge expectation; cherchez le paradox; be sloppy so that something unexpected happens, but not so sloppy that you can’t tell what happened; turn it on its head; never try to solve a problem until you can guess the answer; precision encourages the imagination; seek simplicity; seek beauty. [...] One could do no better than to try them all." (Lewis Wolpert, "The Unnatural Nature of Science", 1992)
"Scientists reach their conclusions for the damnedest of reasons: intuition, guesses, redirections after wild-goose chases, all combing with a dollop of rigorous observation and logical reasoning to be sure […] This messy and personal side of science should not be disparaged, or covered up, by scientists for two major reasons. First, scientists should proudly show this human face to display their kinship with all other modes of creative human thought […] Second, while biases and references often impede understanding, these mental idiosyncrasies may also serve as powerful, if quirky and personal, guides to solutions." (Stephen J Gould, "Dinosaur in a Haystack: Reflections in natural history", 1995)
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