On Conjecture (1950-1974)

"The mathematician as the naturalist, in testing some consequence of a conjectural general law by a new observation, addresses a question to Nature: 'I suspect that this law is true. Is it true?' If the consequence is clearly refuted, the law cannot be true. If the consequence is clearly verified, there is some indication that the law may be true. Nature may answer Yes or No, but it whispers one answer and thunders the other, its Yes is provisional, its No is definitive." (George Pólya, "Induction and Analogy in Mathematics" Vol. 1, 1954)

"We secure our mathematical knowledge by demonstrative reasoning, but we support our conjectures by plausible reasoning. A mathematical proof is demonstrative reasoning, but the inductive evidence of the physicist, the circumstantial evidence of the lawyer, the documentary evidence of the historian, and the statistical evidence of the economist belong to plausible reasoning." (George Pólya, "Mathematics and Plausible Reasoning", 1954)

"Scientific theories are not the digest of observations, but they are inventions - conjectures boldly put forward for trial, to be eliminated if they clashed with observations; with observations which were rarely accidental, but as a rule undertaken with the definite intention of testing a theory by obtaining, if possible, a decisive refutation." (Karl R Popper, "Conjectures and Refutations: The Growth of Scientific Knowledge", 1963)

"We wish to see [...] the typical attitude of the scientist who uses mathematics to understand the world around us [...] In the solution of a problem [...] there are typically three phases. The first phase is entirely or almost entirely a matter of physics; the third, a matter of mathematics; and the intermediate phase, a transition from physics to mathematics. The first phase is the formulation of the physical hypothesis or conjecture; the second, its translation into equations; the third, the solution of the equations. Each phase calls for a different kind of work and demands a different attitude." (George Pólya, "Mathematical Methods in Science", 1963) 

"We defined the art of conjecture, or stochastic art, as the art of evaluating as exactly as possible the probabilities of things, so that in our judgments and actions we can always base ourselves on what has been found to be the best, the most appropriate, the most certain, the best advised; this is the only object of the wisdom of the philosopher and the prudence of the statesman." (Bertrand de Jouvenel, "The Art of Conjecture", 1967)

"All advances of scientific understanding, at every level, begin with a speculative adventure, an imaginative preconception of what might be true. [... This] conjecture is then exposed to criticism to find out whether or not that imagined world is anything like the real one. Scientific reasoning is, therefore, at all levels an interaction between two episodes of thought - a dialogue between two voices, the one imaginative and the other critical [...]" (Sir Peter B Medawar,  "The Hope of Progress", 1972)

"In moving from conjecture to experimental data, (D), experiments must be designed which make best use of the experimenter's current state of knowledge and which best illuminate his conjecture. In moving from data to modified conjecture, (A), data must be analyzed so as to accurately present information in a manner which is readily understood by the experimenter." (George E P Box & George C Tjao, "Bayesian Inference in Statistical Analysis", 1973)

"Statistical methods are tools of scientific investigation. Scientific investigation is a controlled learning process in which various aspects of a problem are illuminated as the study proceeds. It can be thought of as a major iteration within which secondary iterations occur. The major iteration is that in which a tentative conjecture suggests an experiment, appropriate analysis of the data so generated leads to a modified conjecture, and this in turn leads to a new experiment, and so on." (George E P Box & George C Tjao, "Bayesian Inference in Statistical Analysis", 1973)

"[Great scientists] are men of bold ideas, but highly critical of their own ideas: they try to find whether their ideas are right by trying first to find whether they are not perhaps wrong. They work with bold conjectures and severe attempts at refuting their own conjectures." (Karl R Popper, "The Problem of Demarcation", 1974)