"In order to supply the defects of experience, we will have recourse to the probable conjectures of analogy, conclusions which we will bequeath to our posterity to be ascertained by new observations, which, if we augur rightly, will serve to establish our theory and to carry it gradually nearer to absolute certainty." (Johann H Lambert, "The System of the World", 1800)
"In all speculations on the origin, or agents that have produced the changes on this globe, it is probable that we ought to keep within the boundaries of the probable effects resulting from the regular operations of the great laws of nature which our experience and observation have brought within the sphere of our knowledge. When we overleap those limits, and suppose a total change in nature's laws, we embark on the sea of uncertainty, where one conjecture is perhaps as probable as another; for none of them can have any support, or derive any authority from the practical facts wherewith our experience has brought us acquainted." (William Maclure, "Observations on the Geology of the United States of America", 1817)
"The science of the mathematics performs more than it promises, but the science of metaphysics promises more than it performs. The study of the mathematics, like the Nile, begins in minuteness but ends in magnificence; but the study of metaphysics begins with a torrent of tropes, and a copious current of words, yet loses itself at last in obscurity and conjecture, like the Niger in his barren deserts of sand." (Charles C Colton, "Lacon", 1820)
"We know the effects of many things, but the causes of few; experience, therefore, is a surer guide than imagination, and inquiry than conjecture." (Charles C Colton, "Lacon", 1820)
"Let me be permitted to recall that the object of mathematics is not to investigate the causes that one can assign to natural phenomena. This science would lose both its character and credit if, renouncing the support of general well-confirmed facts, it sought within the realm of nebulous conjectures, a realm which has always been a fertile source of error for ways of satisfying the thirst fo rexplanation." (Sophie Germain, "Examen des principes qui peuvent conduire a la connaissance des lois de requilibre et du mouvement des solides elastiques", Annales de Chimie 38, 1828)
"Life is not the object of Science: we see a little, very little; And what is beyond we can only conjecture." (Samuel Johnson, "Causes Which Produce Diversity of Opinion", 1840)
"The entire annals of Observation probably do not elsewhere exhibit so extraordinary a verification of any theoretical conjecture adventured on by the human spirit!" (John P Nichol, "The Planet Neptune: An Exposition and History", 1848)
"The philosophical study of nature rises above the requirements of mere delineation, and does not consist in the sterile accumulation of isolated facts. The active and inquiring spirit of man may therefore be occasionally permitted to escape from the present into the domain of the past, to conjecture that which cannot yet be clearly determined, and thus to revel amid the ancient and ever-recurring myths of geology." (Alexander von Humboldt, "Views of Nature: Or Contemplation of the Sublime Phenomena of Creation", 1850)
"The rules of scientific investigation always require us, when we enter the domains of conjecture, to adopt that hypothesis by which the greatest number of known facts and phenomena may be reconciled." (Matthew F Maury, "The Physical Geography of the Sea", 1855)
"There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact." (Samuel L Clemens [Mark Twain], "Life on the Mississippi", 1883)
"I have been able to solve a few problems of mathematical physics on which the greatest mathematicians since Euler have struggled in vain. [...] But the pride I might have held in my conclusions was perceptibly lessened by the fact that I knew that the solution of these problems had almost always come to me as the gradual generalization of favorable examples, by a series of fortunate conjectures, after many errors." (Hermann von Helmholtz, 1891)
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