On Hypotheses (Null hypothesis)

"In relation to any experiment we may speak of this hypothesis as the null hypothesis, and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis." (Ronald Fisher, "The Design of Experiments", 1935)

"The essential feature is that we express ignorance of whether the new parameter is needed by taking half the prior probability for it as concentrated in the value indicated by the null hypothesis and distributing the other half over the range possible." (Harold Jeffreys, "Theory of Probablitity", 1939)

"What the use of P [the significance level] implies, therefore, is that a hypothesis that may be true may be rejected because it has not predicted observable results that have not occurred." (Harold Jeffreys, "Theory of Probability", 1939)

"As usual we may make the errors of I) rejecting the null hypothesis when it is true, II) accepting the null hypothesis when it is false. But there is a third kind of error which is of interest because the present test of significance is tied up closely with the idea of making a correct decision about which distribution function has slipped furthest to the right. We may make the error of III) correctly rejecting the null hypothesis for the wrong reason." (Frederick Mosteller, "A k-Sample Slippage Test for an Extreme Population", The Annals of Mathematical Statistics 19, 1948)

"Errors of the third kind happen in conventional tests of differences of means, but they are usually not considered, although their existence is probably recognized. It seems to the author that there may be several reasons for this among which are 1) a preoccupation on the part of mathematical statisticians with the formal questions of acceptance and rejection of null hypotheses without adequate consideration of the implications of the error of the third kind for the practical experimenter, 2) the rarity with which an error of the third kind arises in the usual tests of significance." (Frederick Mosteller, "A k-Sample Slippage Test for an Extreme Population", The Annals of Mathematical Statistics 19, 1948)

"It is very easy to devise different tests which, on the average, have similar properties, [...] hey behave satisfactorily when the null hypothesis is true and have approximately the same power of detecting departures from that hypothesis. Two such tests may, however, give very different results when applied to a given set of data. The situation leads to a good deal of contention amongst statisticians and much discredit of the science of statistics. The appalling position can easily arise in which one can get any answer one wants if only one goes around to a large enough number of statisticians." (Frances Yates, "Discussion on the Paper by Dr. Box and Dr. Andersen", Journal of the Royal Statistical Society B Vol. 17, 1955)

"Null hypotheses of no difference are usually known to be false before the data are collected [...] when they are, their rejection or acceptance simply reflects the size of the sample and the power of the test, and is not a contribution to science." (I Richard Savage, "Nonparametric statistics", Journal of the American Statistical Association 52, 1957)

"One feature [...] which requires much more justification than is usually given, is the setting up of unplausible null hypotheses. For example, a statistician may set out a test to see whether two drugs have exactly the same effect, or whether a regression line is exactly straight. These hypotheses can scarcely be taken literally." (Cedric A B Smith, "Book review of Norman T. J. Bailey: Statistical Methods in Biology", Applied Statistics 9, 1960)

"The null-hypothesis significance test treats ‘acceptance’ or ‘rejection’ of a hypothesis as though these were decisions one makes. But a hypothesis is not something, like a piece of pie offered for dessert, which can be accepted or rejected by a voluntary physical action. Acceptance or rejection of a hypothesis is a cognitive process, a degree of believing or disbelieving which, if rational, is not a matter of choice but determined solely by how likely it is, given the evidence, that the hypothesis is true." (William W Rozeboom, "The fallacy of the null–hypothesis significance test", Psychological Bulletin 57, 1960)

"The null hypothesis of no difference has been judged to be no longer a sound or fruitful basis for statistical investigation. […] Significance tests do not provide the information that scientists need, and, furthermore, they are not the most effective method for analyzing and summarizing data." (Cherry A Clark, "Hypothesis Testing in Relation to Statistical Methodology", Review of Educational Research Vol. 33, 1963) 

"[…] most of us still remain content to build our theoretical castles on the quicksand of merely rejecting the null hypothesis." (Marvin D Dunnette, "Fads, Fashions, and Folderol in Psychology", American Psychologist Vol. 21, 1966)

"What used to be called judgment is now called prejudice, and what used to be called prejudice is now called a null hypothesis." (Anthony W F Edwards. "Likelihood", 1972)

"Failing to reject a null hypothesis is distinctly different from proving a null hypothesis; the difference in these interpretations is not merely a semantic point. Rather, the two interpretations can lead to quite different biological conclusions." (David F Parkhurst, "Interpreting Failure to Reject a Null Hypothesis", Bulletin of the Ecological Society of America Vol. 66, 1985)

"A little thought reveals a fact widely understood among statisticians: The null hypothesis, taken literally (and that’s the only way you can take it in formal hypothesis testing), is always false in the real world. [...] If it is false, even to a tiny degree, it must be the case that a large enough sample will produce a significant result and lead to its rejection. So if the null hypothesis is always false, what’s the big deal about rejecting it?" (Jacob Cohen,"Things I Have Learned (So Far)", American Psychologist, 1990)

"The worst, i.e., most dangerous, feature of 'accepting the null hypothesis' is the giving up of explicit uncertainty. [...] Mathematics can sometimes be put in such black-and-white terms, but our knowledge or belief about the external world never can." (John Tukey, "The Philosophy of Multiple Comparisons", Statistical Science Vol. 6 (1), 1991)

"If the null hypothesis is not rejected, [Sir Ronald] Fisher's position was that nothing could be concluded. But researchers find it hard to go to all the trouble of conducting a study only to conclude that nothing can be concluded." (Frank L Schmidt, "Statistical Significance Testing and Cumulative Knowledge", "Psychology: Implications for Training of Researchers, Psychological Methods" Vol. 1 (2), 1996)

"When significance tests are used and a null hypothesis is not rejected, a major problem often arises - namely, the result may be interpreted, without a logical basis, as providing evidence for the null hypothesis." (David F Parkhurst, "Statistical Significance Tests: Equivalence and Reverse Tests Should Reduce Misinterpretation", BioScience Vol. 51 (12), 2001)

"For the study of the topology of the interactions of a complex system it is of central importance to have proper random null models of networks, i.e., models of how a graph arises from a random process. Such models are needed for comparison with real world data. When analyzing the structure of real world networks, the null hypothesis shall always be that the link structure is due to chance alone. This null hypothesis may only be rejected if the link structure found differs significantly from an expectation value obtained from a random model. Any deviation from the random null model must be explained by non-random processes." (Jörg Reichardt, "Structure in Complex Networks", 2009)

"[...] a hypothesis test tells us whether the observed data are consistent with the null hypothesis, and a confidence interval tells us which hypotheses are consistent with the data." (William C Blackwelder)